New chaps in the histone chaperone arena
نویسندگان
چکیده
منابع مشابه
Histone chaperone regulates replication
F orm follows physics in the fl y eye, say The idea that a small set of physical forces governs the shape of tissues goes back at least a hundred years, but there has been little evidence to support it. Now, Hilgenfeldt et al. show that just two parameters— cell elasticity and adhesion strength—can account for the arrangement of cells in the ommatidium, the 20-cell subunit of the fl y's compoun...
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The HIRA chaperone complex, comprised of HIRA, UBN1, and CABIN1, collaborates with histone-binding protein ASF1a to incorporate histone variant H3.3 into chromatin in a DNA replication-independent manner. To better understand HIRA's function and mechanism, we integrated HIRA, UBN1, ASF1a, and histone H3.3 chromatin immunoprecipitation sequencing and gene expression analyses. Most HIRA-binding s...
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Most histone acetyltransferases (HATs) function as multisubunit complexes in which accessory proteins regulate substrate specificity and catalytic efficiency. Rtt109 is a particularly interesting example of a HAT whose specificity and catalytic activity require association with either of two histone chaperones, Vps75 or Asf1. Here, we utilize biochemical, structural, and genetic analyses to pro...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2010
ISSN: 0890-9369
DOI: 10.1101/gad.1946810